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Discovery and optimization of 2-thio-5-amino substituted benzoquinones as potent anticancer agents 期刊论文
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2018, 卷号: 149, 页码: 1-9
作者:  Zhao, Yuqiong;  Lu, Yihuan;  Li, Ridong;  He, Jianan;  Zhang, Han;  Wang, Xin;  Ge, Zemei;  Li, Runtao
收藏  |  浏览/下载:2/0  |  提交时间:2018/05/24
2-Thio-5-amino substituted benzoquinones  Anti-tumor activity  Synthesis  Structure-activity relationship  
Anti-inflammatory effect and mechanism of the spirocyclopiperazinium salt compound LXM-15 in rats and mice 期刊论文
INFLAMMATION RESEARCH, 2018, 卷号: 67, 期号: 4, 页码: 363-370
作者:  Gao, Xiaoli;  Sun, Qi;  Zhang, Weiwei;  Jiang, Yimin;  Li, Runtao;  Ye, Jia
收藏  |  浏览/下载:5/0  |  提交时间:2018/05/24
LXM-15  Anti-inflammation  alpha 7 nicotinic receptor  M4 muscarinic receptor  JAK2/STAT3 signalling pathway  
Antinociception of the spirocyclopiperazinium salt compound LXM-15 via activating alpha 7 nAChR and M4 mAChR and inhibiting CaMKIIa/cAMP/CREB/CGRP signalling pathway in mice 期刊论文
REGULATORY TOXICOLOGY AND PHARMACOLOGY, 2018, 卷号: 94, 页码: 108-114
作者:  Yang, Hua;  Sun, Qi;  Liang, Yingying;  Jiang, Yimin;  Li, Runtao;  Ye, Jia
收藏  |  浏览/下载:1/0  |  提交时间:2018/06/22
Spirocyclopiperazinium salt compound  LXM-15  Antinociception  alpha 7 nicotinic acetylcholine receptor  M4 muscarine acetylcholine receptor  CaMKIIa/cAMP/CREB/CGRP signalling pathway  
A continuous-flow synthesis of primary amides from hydrolysis of nitriles using hydrogen peroxide as oxidant 期刊论文
TETRAHEDRON, 2018, 卷号: 74, 期号: 13, 页码: 1527-1532
作者:  Zhan, Wei;  Ji, Ling;  Ge, Ze-mei;  Wang, Xin;  Li, Run-tao
收藏  |  浏览/下载:0/0  |  提交时间:2018/05/24
Hydrolysis of nitriles  Continuous flow chemistry  Green chemistry  Hydrogen peroxide  
Discovery and structure-activity relationship of novel 4-hydroxy-thiazolidine-2-thione derivatives as tumor cell specific pyruvate kinase M2 activators 期刊论文
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2018, 卷号: 143, 页码: 48-65
作者:  Li, Ridong;  Ning, Xianling;  Zhou, Shuo;  Lin, Zhiqiang;  Wu, Xingyu;  Chen, Hong;  Bai, Xinyu;  Wang, Xin;  Ge, Zemei;  Li, Runtao;  Yin, Yuxin
收藏  |  浏览/下载:3/0  |  提交时间:2018/05/24
PKM2 activators  4-Hydroxy-Thiazolidine-2-thione derivatives  Anti-tumor activity  Structure-activity relationship  
环状磷酰胺氮芥-喹唑啉偶联物的设计、合成及抗肿瘤活性(英文) 期刊论文
Journal of Chinese Pharmaceutical Sciences, 2017, 期号: 10, 页码: 727-736
作者:  陈加贝;  郑育奋;  孔维崎;  李鑫;  罗来春;  韩彦君;  林松文;  孙崎;  葛泽梅;  李润涛
Adobe PDF(858Kb)  |  收藏  |  浏览/下载:0/0  |  提交时间:2018/05/08
磷酰胺氮芥偶联物  抗肿瘤  乳腺癌  表皮生长因子受体-1/2  
An Efficient Cascade Synthesis of Ethyl 3-Amino-5-oxoisoxazolidine-4-carboxylate Derivatives 期刊论文
SYNTHESIS-STUTTGART, 2017, 卷号: 49, 期号: 18, 页码: 4341-4349
作者:  Li, Runrun;  Wei, Qiang;  Wang, Xin;  Ge, Zemei;  Li, Runtao
收藏  |  浏览/下载:7/0  |  提交时间:2017/11/02
Isoxazolidines  Cascade Synthesis  Mild Conditions  Amines  Michael Addition  
Proteasome Inhibitor YSY01A Abrogates Constitutive STAT3 Signaling via Down-regulation of Gp130 and JAK2 in Human A549 Lung Cancer Cells 期刊论文
FRONTIERS IN PHARMACOLOGY, 2017, 卷号: 8
作者:  Huang, Wei;  Yuan, Xia;  Sun, Ting;  Fan, Shujie;  Wang, Jun;  Zhou, Quan;  Guo, Wei;  Ran, Fuxiang;  Ge, Zemei;  Yang, Huayu;  Li, Runtao;  Cui, Jingrong
Adobe PDF(1881Kb)  |  收藏  |  浏览/下载:8/0  |  提交时间:2017/11/02
Proteasome Inhibitor  Ysy01a  Stat3 Signaling  Protein Degradation  Non-small Cell Lung Carcinoma  
Synthesis and biological activity of peptide proline-boronic acids as proteasome inhibitors 期刊论文
BIOORGANIC & MEDICINAL CHEMISTRY, 2017, 卷号: 25, 期号: 15, 页码: 4031-4044
作者:  Han, Liqiang;  Wen, Yanzhao;  Li, Ridong;  Xu, Bo;  Ge, Zemei;  Wang, Xin;  Cheng, Tieming;  Cui, Jingrong;  Li, Runtao
收藏  |  浏览/下载:5/0  |  提交时间:2017/11/02
Proteasome Inhibitor  Peptide Proline-boronic Acid  Antitumor Activity  Subunit Selectivity  Synthesis  
Synthesis of novel five-membered endocyclic sulfoximines 1-aryl-3-(arylimino)-3,5-dihydro-1,4,2-dithiazole 1-oxides 期刊论文
TETRAHEDRON, 2017, 卷号: 73, 期号: 30, 页码: 4387-4391
作者:  Hua, Yong;  Zhang, Wenjie;  Wang, Xin;  Ge, Zemei;  Li, Runtao
收藏  |  浏览/下载:3/0  |  提交时间:2017/11/02
Five-membered Endocyclic Sulfoximines  Chloromethyl Aryl Sulfoximines  Aryl Isothiocyanates  Addition/cyclization  Synthesis